Those with Nrf2 Deficiency May Be More At Risk from Potential Changes in Minnesota Manganese Laws!

I hope the health department looks at the consequences of changes like these considering the new research on the health effects of toxic metals. Especially that certain polymorphisms in this system and the genes it regulates may put people and animals more at risk for permanent health effects including neurological and cognitive impairment that may be permanent and can be passed on to future generations. Since polymorphisms exist in populations and their descendants in Minnesota -- I hope the health department understands the consequences related to environmental justice issue considering in addtion to population factors, the economic and environmental factors related to where the sulfide mines are being proposed.  "The Nrf2 antioxidant system may play a role in protection against manganese toxicity. It is expected that the PolyMet mine will leach manganese from tailings."

"This may be hard to understand, but just as the pressure builds to permit sulfide mining and processing, the Minnesota Health Department is proposing to repeal the Health Risk Limits that protect Minnesota drinking water from overly high levels of manganese contamination."

Will Minnesota Lose Protection from Manganese Pollution in Drinking Water? | Just Change Law:

Source#2: Li, H., Wu, S., Shi, N., Lin, W., You, J., and Zhou, W. (2010). NF-E2-related factor 2 activation in PC12 cells: its protective role in manganese-induced damage. Archives of toxicology, pages 1-10. http://www.citeulike.org/user/HEIRS/article/8337080